Actinobacillus equuli is a common resident of the oral cavity of horses. In young foals it can cause acute septicaemia and sequelae such as arthritis and pleuritis. Little is known about the pathogenesis of A. equuli and its identification can be problematic due to its similarity with Actinobacillus suis. Shotgun whole genome sequencing of Actinobacillus equuli equuli ATCC 19392 was done by pyrosequencing. Preliminary analysis of the data revealed that the A. equuli genome is ~2.37 Mb and has ~2200 protein coding genes and a G+C content of ~40.3%. Chromosome alignment using progressive Mauve showed that the A. equuli equuli genome is very similar to that of A. suis H91-0380 and is largely syntenic. Many of the putative virulence factors of A. suis are present in the A. equuli genome including 8 autotransporters which share between 48 and 97% identity; 12 OMPs (76 to 100% identity); type IV pilus genes (90 to 99% identify) and a tad locus containing genes with 73 to 99% identity. In addition, genes with homology to apxIB, apxID, apxIA/apxIIA, and apxIC were detected as was the urease operon and genes encoding proteins for the uptake of transferrin, haemoglobin, and siderophores. A. pleuropneumoniae type uptake signal sequences are present; and although genes encoding homologs of ComE, Com F and ComM are present, other competence genes were not detected.